Manly Memorial Baptist Church at dusk; corner of Main and Preston streets.
"Manly" does not refer to the character of the congregation (though I wouldn't like to rule it out), but to the church's early 20th C. namesake. Formerly Lexington Baptist, it became"Manly Memorial" in honor of Dr. Charles Manly, pastor from 1903-1914. (The church's website states that in his day he was known as the "most universally beloved man in Lexington.")
The present church was built in 1920, in a rather eclectic style. In addition to the dome, Ionic capitals (above smooth, unfluted columns), and heavy, dentiled cornices, there is an impressive amount of contemporary stained glass in soft, opalescent colors -- greens, blue-greens, warm browns, lavenders and pinks -- that make a strange and interesting contrast to the brick and the many classical references.
Here is an example:
It's a very American ("Rules? -- what rules?") structure that, not surprisingly, also appears to take inspiration from Thomas Jefferson's Monticello (located about 56 miles [91 km] NE of Lexington, as the crow flies).